Open access
Jul 2026
Fragmentation of Vancoresmycin Reveals a Strong Dependence on Global Molecular Architecture for Antibacterial Activity
It is demonstrated that antibacterial activity in vancoresmycin cannot be attributed to isolated substructures but instead depends on the integrated molecular architecture, providing a framework for future design strategies that preserve global structural properties rather than focusing on discrete motifs.
Max Schönenbroicher, Florian Heppner, Maximilian Seul et al.
· ChemMedChem · 0 citations