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Simon Schenk

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Open access Oct 2026

Cardiomyocyte Perm1 sustains cardiac bioenergetic reserve and exercise capacity

Objective The PGC-1/ERR axis controls both steady-state mitochondrial respiration and the capacity to expand ATP production on demand, but whether this reserve function requires dedicated downstream effectors, and whether its loss is detectable at rest, remain unclear. We tested whether Perm1, a striated muscle-specifi...

Shizuko Tachibana, Tina Le, Simon Schenk et al. · 0 citations

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