Open access
Jul 2026
Metformin improves mitophagy-related pathways and mitochondrial-lysosomal homeostasis in chromosome 21 trisomic fibroblasts
The findings support mitophagy inefficiency due to pathway saturation as a key pathogenetic mechanism in trisomic cells and identify metformin as a pharmacological tool capable of relieving the proteostatic overload intrinsic to trisomy 21.
Nunzia Mollo, Rosalba Natale, M. D’Ariano et al.
· Cellular and Molecular Life... · 0 citations