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These findings identify pDCs as antigen-presenting cells involved in coordinating the immune response to BNT162b2, and pDCs appear to play a functional role in the efficacy of this mRNA vaccine.
These findings expand the genetic, structural and functional landscape of human antibody responses to conserved coronavirus S2 epitopes and demonstrate that CH-directed antibodies can contribute to protective immunity through Fc-dependent mechanisms not predicted by in vitro neutralization or conventional in vitro Fc e...
The feasibility and efficacy of this novel mini-body-based strategy as a viable therapeutic modality for targeting an oncogenic transcription factor previously considered undruggable are established and supports further translational development for targeting ERG-driven prostate cancer.
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