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Simone Mader

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Open access Oct 2026

A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity

T and B cell–mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein–Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-specific T cells contribute remains unclear. We generated an antigen-resolved atlas of blood and cerebrospinal fluid (CSF...

N. Kristensen, T. Tsaktanis, S. Frischholz et al. · 0 citations
Open access Oct 2026

T-B interactions yield CD3+ B cells and CD20+ T cells with pathogenic features in multiple sclerosis.

Classically, B and T cells are differentiated by their mutually exclusive expression of surface markers such as CD3 and CD20, but it is now established that a few percent of T cells in human blood display also CD20. We analyzed CD3+CD20+ cells in detail by combining single-cell proteogenomics, FACS, and ImageStream. Th...

Selia Baier, Zhong-Yi Wang, N. Loll et al. · 0 citations

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