Effects of sulfamethoxazole and trimethoprim on Phaeodactylum tricornutum and Skeletonema costatum: growth, oxidative stress, biochemistry, attenuation, transcriptome and metabolome.
Trimethoprim (TMP) and sulfamethoxazole (SMX) are commonly detected antibiotics in marine environments, yet their potential hazards to marine microalgae under co-occurrence remain poorly understood. This study investigated the combined toxic effects of environmentally relevant concentrations of TMP (200 ng/L) and SMX (...