Open access
Aug 2026
Spatial Profiling Reveals Immune Escape Pathways and Therapeutic Vulnerabilities in Prostate Cancer Bone Metastases.
Bone metastases showed marked suppression of tumor-intrinsic type I interferon (IFN-I) signaling and loss of antigen presentation, features that were strongly associated with reduced bone metastasis-free survival and could inform precision therapeutic strategies for PCa.
Katie L. Owen, L. Gearing, B. Niranjan et al.
· Cancer Research · 0 citations