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Author

Siyu Chen

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2 papers indexed here

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Aug 2026

Discovery of Polycyclic Polyprenylated Acylphloroglucinols from Hypericum androsaemum as Dual-Mechanism Inhibitors of Mycobacterium tuberculosis GlmU Acetyltransferase.

(±)-Hypericandrone A and (+)-1 displayed potent antitubercular activity by selectively inhibiting the acetyltransferase domain of Mycobacterium tuberculosis GlmU through a dual mechanism, acting competitively against acetyl-CoA and noncompetitively against glucosamine-1-phosphate.

Jiang-Chun Wei, Xing-Piao Jin, Xiang-Wang Zhao et al. · 2 citations
Aug 2026

10,11-Dehydrocurvularin suppresses non-small cell lung cancer by targeting PAICS and inducing apoptosis.

Non-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related mortality worldwide, highlighting the urgent need for effective therapeutic agents. Natural products represent an important source of novel anticancer compounds. In this study, we investigated the anti-NSCLC activity of 10,11-dehydro...

Yue Wang, Siyu Chen, Ping Huang et al. · 0 citations

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