Open access
Aug 2026
Overcoming the blood-brain barrier using central nervous system-accessing lipid nanoparticles for enhanced mRNA therapeutics.
This work designed, synthesized, and tested a series of ionizable lipids and formulated them into CNS-accessing lipid nanoparticles (CA LNPs) to deliver mRNA, and the lead candidate, CA2d LNP, demonstrated efficient mRNA delivery across the blood-brain barrier following intravenous injection.
Si-Yu Wang, Yi-Chen Zhong, Chang Wang et al.
· Proceedings of the National... · 0 citations