Smita Krishnaswamy

Mapping Alzheimer’s neuropathology signatures to the whole brain transcriptome using machine learning data-fusion

In Alzheimer’s disease (AD), misfolded proteins emerge across the entire brain in structured, yet not rigid, spatiotemporal patterns. Yet, a systematic bias of single-cell genomics toward sampling mostly cortical tissue limits our understanding of the whole-brain transcriptomic vulnerability to AD. Here, we develop a m...