Open access
Aug 2026
Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to promote goal-directed action
It is found that glutamatergic axon terminals from the basolateral amygdala evoke striatal dynorphin release, resulting in feed-forward retrograde presynaptic GPCR inhibition to promote behavior, and subsequent GPCR activity for promoting goal-directed behavior.
Raajaram Gowrishankar, Madelyn M. Hjort, Abigail J. Elerding et al.
· Cell · 1 citation