Open access
Sep 2026
System biology analysis reveals circadian rhythm disorder associated with development and progression in colorectal cancer
The ClockProCRC system is developed and validated, which detects and quantifies intrinsic circadian misalignment in CRC and elucidates how circadian misalignment drives CRC progression trajectories, shapes clinical phenotypes, regulates disease manifestations, and reshapes the tumor microenvironment.
Shi-Qian Zhang, Shan-Shan Cai, Nai-Jing Hou et al.
· npj Precision Oncology · 0 citations