Sep 2026
Temporal regulation of progenitor lineage progression and output by NFIs underlying human neocortical malformation.
Nuclear factor I (NFI) misexpressions in humans are associated with severe brain malformations, yet the underlying mechanisms remain poorly understood. Here, we show that NFIs regulate the broad lineage progression and lifespan of radial glial progenitors (RGPs), thereby bidirectionally controlling neocortical developm...
Qiang-Qiang Zhang, Guo-Hua Yuan, E. Albizzati et al.
· Neuron · 0 citations