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Open access Sep 2026

A cfDNA fragmentomics-based machine learning model for predicting treatment response and recurrence in locally advanced rectal cancer after neoadjuvant chemoradiotherapy

Neoadjuvant chemoradiotherapy (nCRT) is standard treatment for locally advanced rectal cancer (LARC), but responses vary substantially. We developed Fragmentia-AI Response, a machine learning model that uses cell-free DNA (cfDNA) fragment features to predict pathological response and recurrence risk without relying on...

Kun Miao, Song Wang, Guo-Feng Sun et al. · 0 citations

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