Song Yang

GRP75-dependent SIMPA mediates inter-organellar quality control.

Targeting heparanase-associated epithelial glycocalyx remodeling attenuates Akt/NF-κB–related barrier dysfunction in experimental COPD

Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation, epithelial barrier dysfunction, and progressive structural remodeling. Although glycocalyx impairment has been implicated in COPD pathogenesis, the mechanisms linking glycocalyx degradation to epithelial barrier...

A novel flavonoid derivative for treating colorectal cancer by suppressing tumor angiogenesis through VEGFR2 inhibition.

In vitro and in vivo studies confirmed that 27j effectively inhibits key angiogenetic processes and interferes with VEGFR2 activation and its downstream signaling, supporting its further investigation as a promising lead compound for anti-tumor angiogenesis therapy.