Oct 2026
De Novo Structural Mining and Engineering of TadA Deaminases for High Efficiency Adenine Base Editors.
Bo-Hong Chen, Bao-Ting Nong, Shao-Yun Lin et al.
· Molecular Therapy · 0 citations
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Open access
Aug 2026
MYDGF as a telomerase activator and therapeutic target for osteoarthritis
Osteoarthritis (OA) involves progressive cartilage breakdown. This is driven by impaired chondrocyte function and an imbalance in the extracellular matrix homeostasis. However, the key upstream regulators that maintain healthy chondrocytes are still not fully known. Here, we report that myeloid-derived growth factor (M...
Yi-Jun He, Chu-Jun Li, Ke-Xin Chen et al.
· Advanced Biotechnology · 0 citations
Open access
Jul 2026
Secreted protein combination GAPDH/S100A8/S100A9 from human expanded potential stem cells counteracts mesenchymal stromal cell senescence
Human mesenchymal stromal cells (hMSCs) remain the most clinically advanced adult stem cell source; however, their therapeutic potential is limited by rapid replicative senescence during ex vivo expansion. Replicative senescence in hMSCs is characterized by cell cycle arrest, acquisition of senescence-associated β-gala...
Qingcai Feng, Qianwen Pang, Hongyu Lu et al.
· Stem cell research & therape... · 0 citations