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Phytochemical analysis revealed that flavonoids and phenolic acids were the dominant constituents, with chlorogenic acid, rutin, quercetin, kaempferol, and gallic acid as the major compounds, particularly enriched in methanolic extracts.
Docking supported preferential hydrophobic binding to hyaluronidase/collagenase pockets, aligning with bioassay selectivity and permeability predictions, and ICP-MS indicated essential minerals with sporadic heavy-metal signals, supporting purification before topical development.
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