Sophia M. Perrakis

Casp1 and Ripk3 are required for homeostatic insulin secretion in mice

Objectives Cell death and inflammatory pathways play important roles in adaptations to nutrient overload and metabolic dysfunction. This study investigates the metabolic consequences that arise from the dual disruption of both caspase 1 (Casp1) and receptor interacting protein kinase 3 (Ripk3) in mice fed a control or...