Open access
Aug 2026
GFAP upregulation by astrocytes attenuates tau neurofibrillary tangle pathology in a mouse model of tauopathy
The upregulation of the intermediate filament glial fibrillary acidic protein (GFAP) by reactive astrocytes has been traditionally assigned structural functions such as the shaping of astrocyte morphology and the formation of the glial scar. However, in vitro studies have also implicated GFAP in chaperone-mediate...
C. Muñoz-Castro, Molly A. Healey, Ayush Noori et al.
· Molecular Neurodegeneration · 0 citations