Primary cilia, which are present in most brain cells, are essential for brain development and function. During early brain development, dysfunction of the primary cilia can lead to a broad spectrum of disorders, collectively termed ciliopathies, that include brain malformations and intellectual disability. Although the...
Tae-Yeon Eom, I. Bayazitov, B. J. Teubner et al.· bioRxiv· 0 citations
Synaptic vesicle cycling, if not properly constrained, can result in excessive neurotransmitter release and subsequent neural pathology. Rab GTPases orchestrate synaptic vesicle trafficking through GTP-dependent interactions with effector proteins, but the restraining mechanism of these interactions is unknown. Here we...
Dušan Garić, Jonathan G. Murphy, B. J. Teubner et al.· bioRxiv· 0 citations
Synaptic vesicle cycling, if not properly constrained, can result in excessive neurotransmitter release and subsequent neural pathology. Rab GTPases orchestrate synaptic vesicle trafficking through GTP-dependent interactions with effector proteins, but the restraining mechanism of these interactions is unknown. Here we...
Dušan Garić, Jonathan G. Murphy, B. J. Teubner et al.· bioRxiv· 0 citations
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