Type 2 diabetes mellitus (T2DM) develops through the interplay of insulin resistance and progressive beta-cell dysfunction. Beyond genetic predisposition, epigenetic regulation provides a mechanistic link between environmental exposures (e.g., overnutrition, physical inactivity, inflammation) and durable changes in gen...
Marina Spaho, Fotios Karytis, Stavros P. Papadakos et al.· HORMONES· 0 citations
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and are usually driven by activating mutations in KIT or PDGFRA. Although these alterations define the core molecular biology of GISTs and guide targeted therapy, they do not fully explain the variability observ...
Georgios Mandrakis, Stavros P. Papadakos, Georgia Levidou et al.· International Journal of Mol...· 0 citations
Socioeconomic deprivation is linked to lower bowel cancer screening uptake, potentially resulting in later-stage colorectal cancer (CRC) diagnoses. This retrospective study explored whether it influences CRC stage at diagnosis and time to first treatment (TFT).
Anonymised patient data were sourced from Low...
Ioannis Karniadakis, Stavros P. Papadakos, C. Tsagkaris et al.· British Journal of Surgery· 0 citations
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