Author

S. Prokop

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Open access Aug 2026

Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasis

Background Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) are components of the amyloid deposits in Alzheimer’s disease (AD) and other amyloidoses. HS and HSPGs are canonically thought to facilitate amyloid deposition by accelerating the aggregation of amyloidogenic proteins and impairing their clearanc...

K. Shim, Yong Ran, Danny Ryu et al. · bioRxiv · 0 citations

Open access Aug 2026

Corpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains

Summary Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here, we profile corpora amylacea (CA) in 230 postmortem human brains, revealing significantly higher densities in Alzheimer’s disease (AD) patients when compared wi...

Jonathan A. B. Villareal, Tim Bathe, Ana de la Rosa et al. · Cell Reports Medicine · 0 citations