Open access
Aug 2026
IL-15 boosts mesothelin- and CD70-CAR NK cell potency in PDAC without added benefit from dual targeting
Chimeric antigen receptor (CAR) therapies have shown great success in hematological malignancies but remain largely ineffective against solid tumors such as pancreatic ductal adenocarcinoma (PDAC). A key obstacle among various aspects, is the dense stromal barrier formed by cancer-associated fibroblasts (CAFs), providi...
Laura Gehrcken, J. Ott, Astrid Van Den Eynde et al.
· Molecular therapy. Oncology · 0 citations