Stefano Comazzetto

Vitamin C promotes differentiation of stress-specific erythroid progenitors in stress erythropoiesis.

We discovered that vitamin C import through the vitamin C transporter SLC23A2 in stress-specific erythroid progenitors represents a key regulatory nexus in the recovery of the erythron. In response to erythroid stress, such as blood loss, Epo induces the expression of Slc23a2 in stress erythroid progenitor cells, incre...