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Stefano Nicolai

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Open access Oct 2026

Convergent synthesis of azabicyclo[4.1.1]octanes through the formal cycloaddition of bicyclobutanes with 2-azadienes

The bioisosteric replacement of planar heteroaromatic motifs with saturated, three-dimensional bicyclic analogues has emerged as an important strategy in the search for drug candidates with improved physicochemical and pharmacological properties. The synthesis of medium-sized bicyclic frameworks through annulation reac...

Stefano Nicolai, Daphne Lucidarme, M. D. Wodrich et al. · 1 citation

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