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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Steffen Boettcher

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2 papers indexed here

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Sep 2026

SLIT2 modulates leukaemic cell proliferation and stromal support in acute myeloid leukaemia models.

Acute myeloid leukaemia (AML) is supported by leukaemic stem cells (LSCs), whose continued existence and growth are dependent upon signals derived from their bone marrow (BM) microenvironment. Although the highly conserved glycoprotein slit guidance ligand 2 (SLIT2), implicated in axon guidance, has been proposed to su...

Luise Albuquerque-Simões, I. Weinhäuser, D. Pereira-Martins et al. · 0 citations
Aug 2026

Dual MYC and GSPT1 Protein Degrader for MYC-Driven Hematologic Malignancies.

Direct targeting of the oncoprotein MYC has not yet been successful. We here report a novel dual protein degrader, GT19630, which binds directly to MYC and G1 to S phase transition protein 1 (GSPT1). GT19630 disrupts a novel feedforward loop of MYC and GSPT1, where MYC promotes transcription of GSPT1, and GSPT1 senses...

Yuki Nishida, Valeria Impedovo, Edward Ayoub et al. · 0 citations

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