Author

Stephan Herzig

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Open access Sep 2026

Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity

Non-coding RNAs from the Dlk1-Dio3 locus are critical for the maturation of metabolic tissues in early stages of postnatal development; however, their role in the mature organs remains elusive. Herein, we show that microRNAs from the miR-379/miR-410 cluster are robustly upregulated in livers of subjects with obesity an...

Manuel Gil-Lozano, E. Simoes, Mo-Ya Wu et al. · Nature Communications · 0 citations

Open access Sep 2026

mTORC1-TFEB/TFE3 signaling is associated with bile acid diversification during hepatic metabolic adaptation

The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal cues to regulate hepatic lipid metabolism with major implications for metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that altered hepatic mTORC1–TFEB/TFE3 signaling is associated with coordinated rem...

A. Zaufel, Wenfei Sun, N. Pastore et al. · Science Advances · 0 citations

Open access Sep 2026

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.

Cancer cachexia is a devastating wasting syndrome with no approved therapies. In this study, we identify the tumor-derived glycoprotein ADAMTSL4 as a circulating factor associated with body weight loss in preclinical cachexia models and patients with colorectal and lung cancers. In mice, Adamtsl4 overexpression convert...

J. Machado, Vignesh Karthikaisamy, Hermine Mohr et al. · Cancer Discovery · 0 citations