Open access
Sep 2026
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
ABSTRACT Gene therapies using adeno‐associated viruses (AAVs) for central nervous system (CNS) disorders face challenges because host immune responses are not represented in classical preclinical models. Here, we present a human‐induced pluripotent stem cell (hiPSC)‐derived innate immunocompetent 3D CNS model that reca...
C. M. Gomes, Gabriela Silva, Mafalda Aleixo et al.
· Advancement of science · 0 citations