Open access
Sep 2026
Interpretable spherical geometry of single-cell state transitions from dominant principal components
Single-cell RNA-seq atlases are commonly explored with nonlinear embeddings that preserve neighborhoods but provide limited coordinate-level interpretation. We asked whether projecting the dominant principal components (PCs) of single-cell gene expression onto a unit sphere would yield an interpretable coordinate syste...
Long Yuan, Xu-Yang Li, My Le et al.
· bioRxiv · 0 citations