Author

Stephen J. Nicholls

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Open access Aug 2026

Retatrutide-Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes.

AIMS To further characterise the effects of retatrutide on cardiometabolic risk, lipoprotein and inflammatory biomarkers were assessed post hoc in phase 2 trials of adults with obesity/overweight with or without type 2 diabetes (T2D). MATERIALS AND METHODS Data were analysed from two randomised, double-blind, placebo...

G. Ruotolo, C. Harris, Yanzhu Lin et al. · Diabetes, obesity and metabo... · 0 citations

Aug 2026

Cumulative Benefit With Evolocumab in Patients With No Prior Myocardial Infarction or Stroke in the VESALIUS-CV Study.

BACKGROUND Proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab reduced the risk of a first major adverse cardiovascular event (MACE) in patients at high cardiovascular risk with no prior myocardial infarction (MI) or stroke in the VESALIUS-CV (Effect of Evolocumab in Patients at High Cardiovascular...

José C. Nicolau, Sabina A. Murphy, Robert P. Giugliano et al. · Journal of the American Coll... · 1 citation

Open access Sep 2026

Sex Differences in Coronary Atheroma Regression After Intensive Lipid-Lowering Therapy: A Pooled Analysis.

BACKGROUND Intensive lipid-lowering therapy with high-intensity statins, with or without proprotein convertase subtilisin/kexin type 9 inhibitors, reduces coronary plaque burden. However, whether men and women experience similar atheroma regression and plaque compositional changes remains uncertain. OBJECTIVES The ob...

A. Bansal, J. St. John, R. Puri et al. · JACC: Advances · 0 citations