Author

Stephen K. Anderson

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Open access Oct 2026

Dual inhibition of JAK and MEK suppresses T-cell acute lymphoblastic leukemia induced by mutant IL7R and RASGRP1 overexpression.

Gain-of-function mutant IL-7Rα (mutIL7R) occurs in approximately 10% of patients with Tcell acute lymphoblastic leukemia (T-ALL), an aggressive pediatric cancer. Nearly half of patients with T-ALLs also overexpress RAS guanyl nucleotide exchange factor (RASGRP1), an activator of RAS. Since mutant RAS itself has been sh...

Steven Hsu, Gisele O. L. Rodrigues, Nathan Wong et al. · Haematologica · 0 citations

Open access Sep 2026

IL-15 signaling during a critical NK cell developmental window subverts maturation and KIR acquisition.

Natural killer (NK) cells are key mediators of immune surveillance following hematopoietic stem cell transplantation (HSCT). However, despite the post-conditioning spike in interleukin-15 (IL-15), NK cell maturation is frequently delayed following HSCT. Here, we show that during in vitro NK cell development from CD34+...

Michael A. Ruesch, Noah T. Koenigs, E. Troy et al. · Cell Reports · 0 citations