Open access
Sep 2026
Self-supervised missing-wedge correction enables accurate cellular morphology and volume reconstruction in soft X-ray tomography.
Soft X-ray tomography (SXT) bridges the resolution gap between fluorescence and transmission electron microscopy for 3D cellular imaging. However, the missing-wedge artifact from incomplete tilt-series acquisition causes systematic structural elongation, thereby overestimating organelle volumes and compromising quantit...
Sen-Chueh Shao, Mary Lopez-Perez, Charlotte de Ceuninck van Capelle et al.
· Cell Reports Methods · 0 citations