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Author

Steven S. Rosenfeld

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Open access Aug 2026

Intracranial Targeting of Cholesterol Processing Reveals a Therapeutic Vulnerability that Reprograms Glioblastoma and Promotes Antitumor Immunity

These findings establish cholesterol dysregulation–induced metabolic collapse as a promising therapeutic approach for GBM using two FDA-approved drugs: the H1 histamine antagonist clemastine and the retinoid X receptor agonist bexarotene.

Maria J. Ulloa-Navas, Rachel M. Whitehead, Vanessa K. Jones et al. · 0 citations
Open access Jul 2026

Glioblastoma Subtypes Exhibit Distinct Migration Mechanics and Immune Responses

Mesenchymal tumors have aggressive migration but are immunologically “hot,” which suppresses net proliferation and may explain the lack of a strong survival difference between subtypes clinically, while also opening up new opportunities for subtype-specific therapies.

Ghaidan A Shamsan, Chao J. Liu, B. Braman et al. · 0 citations

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