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Stuart J. Conway

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Open access Jul 2026

Discovery of a phenazine–thiol conjugase from sparse data using genome-informed machine learning

It is shown that integrating genome-informed data augmentation with contrastive learning in protein language space enables identification of phenazine-interacting proteins starting from only 14 known phenazine modifying sequences, and coupling comparative genomics with protein machine learning can convert “small data” typically outside the scope of machine learning into actionable predictive power, thereby facilitating enzyme discovery.

Xiaoyu Shan, I. Trindade, N. Glasser et al. · 0 citations
Open access Jul 2026

Targeting RNA-Binding Oncofetal Protein IGF2BP3: Discovery of Potent and Selective Inhibitors

Beyond enabling the discovery of several new potent and selective small molecules, these studies have allowed us to elucidate key parameters for potency, selectivity, and metabolic stability that should aid future efforts in RBP drug discovery.

G. M. Scherer, Jacob P. Sorrentino, A. K. Jaiswal et al. · 0 citations