Su-Chi Lim

β-hydroxybutyrate as an early predictive biomarker of diabetes remission following intensive dietary intervention

Pathway-Specific Polygenic Risk Score and Risk of Hyperglycaemic Progression in Patients With Type 2 Diabetes.

AIM Pathway-specific polygenic risk scores (psPRS) provide insights into the heterogeneity of type 2 diabetes. We aim to study whether psPRS for beta cell dysfunction, obesity and metabolic syndrome associate with risk of hyperglycaemic progression in Southeast Asian patients with type 2 diabetes. PARTICIPANTS AND ME...

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end-stage renal disease

End-stage renal disease (ESRD) remains a major clinical challenge with high morbidity and mortality, and its molecular mechanisms, particularly those shared among diverse primary kidney diseases during progression to ESRD, have not been studied. Here we conduct a large-scale two-stage epigenome-wide association study o...

Proteomic signatures of loss of glycemic control in youth-onset type 2 diabetes in the TODAY study.

Novel proteins involved in axon guidance, immune response, inflammation, and metabolism associated with LOGC in youth-onset T2D with proteins demonstrating consistent associations across the lifespan and proteomic platforms are identified.

Plasma Proteins Associated With Incident Acute Myocardial Infarction in Asians With Type 2 Diabetes.

Plasma proteomics improves AMI risk stratification in T2D, and FGF5 may play a role in cardiovascular risk in Asian populations.