Su-Hua Zhu

Targeting Iron Regulatory Protein 2 in Tumor-associated Macrophages Activates Antitumor Immunity in NSCLC via Modulating SphK1-PD-L1 Axis

IRP2-dependent maintenance of the immunosuppressive TAM phenotype as a promising therapeutic target in NSCLC is identified, finding that IRP2 skewed TAMs toward an immunosuppressive state that promoted tumor cell proliferation and migration, and limited apoptosis.