All-trans retinoic acid-driven immune remodeling in esophageal squamous cell carcinoma revealed by single-cell transcriptomics.
Esophageal squamous cell carcinoma (ESCC) remains a highly lethal malignancy with limited durable responses to current therapies. Our previous work showed that all-trans retinoic acid (ATRA) upregulates the deubiquitinase OTUD6B and suppresses ESCC stemness. Here, we integrated in vivo pharmacological treatment, single...