Single-cell–informed senescence programs underpin a machine-learning prognostic model robustly validated across melanoma cohorts
Background Cellular senescence (CS) shapes tumor evolution and the tumor microenvironment (TME), yet senescence-informed prognostic models for skin cutaneous melanoma (SKCM) remain limited. We aimed to develop and validate a robust senescence-related prognostic signature by integrating single-cell and bulk transcriptom...