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Open access Sep 2026

Single-cell–informed senescence programs underpin a machine-learning prognostic model robustly validated across melanoma cohorts

Background Cellular senescence (CS) shapes tumor evolution and the tumor microenvironment (TME), yet senescence-informed prognostic models for skin cutaneous melanoma (SKCM) remain limited. We aimed to develop and validate a robust senescence-related prognostic signature by integrating single-cell and bulk transcriptom...

Su Peng, Jia-Heng Xie, Xiao-Hua He · 0 citations

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