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Author

Subhrajit Saha

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Review Open access Oct 2026

Pancreatic acinar cell carcinoma demonstrates marked clinical heterogeneity and recurrent actionable genomic alterations

Pancreatic acinar cell carcinoma (PACC) is a rare pancreatic malignancy with a molecular profile distinct from pancreatic ductal adenocarcinoma (PDAC) but is commonly treated using extrapolated paradigms. We retrospectively identified patients with histologically confirmed PACC at a tertiary academic center...

Noor Farhoud, R. Al-Rajabi, J. Baranda et al. · 0 citations
Jul 2026

Abstract A080: Activation of hSSB2/1 by BCN077 Induces Tumor-Selective Mitotic Catastrophe While Protecting Irradiated Epithelium: A New Therapeutic Paradigm for Expanding the Cancer Treatment Window

Findings support a mechanism in which hSSB2 activation intensifies genotoxic stress beyond the tolerable threshold in cancer cells while reinforcing recovery and survival programs in normal tissues, representing a genuine translational opportunity to expand the therapeutic window of radiation and chemotherapy.

Andrew Norris, Elizabeth M. Singer, R. Chugh et al. · 0 citations

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