Open access
Aug 2026
Naringenin as a dual-target modulator of RAGE–NF-κB signaling and Aβ fibrillization in Alzheimer’s disease: integrated computational and experimental analyses
NAR reduced Aβ42-induced NF-κB activation in RAGE-positive C6 cells, protected SH-SY5Y neurons from Aβ42 toxicity, and inhibited Aβ42 fibrillization in vitro, producing non-seeding aggregates consistent with impaired fibril formation, and attenuated rotenone-induced α-synuclein-associated cellular stress.
Inderjeet Bhogal, I. Frydrych, Ajay Modi et al.
· Frontiers in Pharmacology · 0 citations