Targeting the P2X7–NLRP3 Inflammasome Axis in Obesity: Circadian Regulation of Metabolic Inflammation and Disease Progression
This study signifies the mechanisms underlying circadian regulation of the P2X7–NLRP3 axis, its tissue-specific roles in obesity, and available preclinical and clinical evidence, and further review innovative therapeutics like inflammatory inhibiting targets including inflammasome inhibitors, P2X7 antagonists and chron...