Aug 2026
Mechanistic Roles of Conserved Active-Site Residues in OXA-48 Carbapenem Hydrolysis.
Results support a model in which conserved hydrophobic active-site residues optimize the geometric and electrostatic environment required for efficient carbapenem deacylation and turnover, and provide mechanistic insight into OXA-48 catalysis that may be exploited to design inhibitors targeting the enzyme.
DorisMia Taylor, D. Ngango, Jia-Yi Fan et al.
· ACS Infectious Diseases · 0 citations