Open access
Jul 2026
Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease
QA activates a microglia-specific signaling cascade that promotes PE biosynthesis and GAP, thereby enhancing Aβ clearance and mitigating AD pathology, and reveals a paradoxically beneficial role of QA in activating a microglia-specific signaling cascade that promotes PE biosynthesis and GAP.
Seung Jae Hyeon, Seungchan Kim, Jiyeon Chu et al.
· Signal Transduction and Targ... · 2 citations