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ABSTRACT Antigen‐loss variants (ALVs) are a major cause of relapse following chimeric antigen receptor (CAR) T cell therapy, particularly in solid tumors where antigen heterogeneity and immune suppression prevail. By integrating public single‐cell RNA sequencing analysis with experimental validation, we identify the tr...
Findings suggest that BBP exposure is associated with alterations in vascular inflammatory processes involving MMP9 and CXCR2, and provides evidence supporting an inflammatory recruitment mechanism involving MMP9 and CXCR2 in BBP-associated vascular responses and offers a framework for future investigation into the con...
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