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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Suin Kim

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Open access Sep 2026

Structure-based rational design and biological evaluation of a quinazoline-based EGFR exon 20 insertion inhibitor.

This study describes the structure-based design and synthesis of potent quinazoline-based inhibitors targeting EGFR exon 20 insertion (exon20ins) mutants, one of the challenging oncogenic drivers in non-small cell lung cancer (NSCLC). Guided by in silico modelling, a novel series of quinazoline analogues was designed t...

Sooheum Jo, Hyunsoo Jang, Suin Kim et al. · 0 citations

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