Hypoxia-inducible factor 1 (HIF-1) orchestrates the transcriptional regulation of thousands of genes involved in breast cancer (BC) progression. Here, we identified protein phosphatase 2A (PP2A) methylesterase 1 (PPME1) as a critical HIF-1 target gene that drives oncogenic signaling under hypoxic conditions. In BC cell...
Yajing Lyu, Varen Talwar, Yong-Kang Yang et al.· Journal of Clinical Investig...· 0 citations
The data show that nanoscale aAPCs reliably expand functional antigen-specific CD4 T cells from human PBMCs, providing both mechanistic insight into cytotoxic CD4 biology and a translational foundation for antigen-specific cell immunotherapy.
Si-Sim Kang, Mu-Qing Zhang, Shuyi Li et al.· Journal of Immunology· 0 citations
It is shown that aAPCs can drive differentiation of CD4 CTL in vitro and are tunable by cytokine concentration and milieu, particle size, and antigen specificity, which lays the groundwork for further investigation of this non-canonical T-cell subset.
Mara R Lanis, Sujin Kim, Nina M. Nair et al.· Journal of Immunology· 0 citations
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