Molecular Mechanisms and Current Research Status of Salvianolic Acid B in the Treatment of Cardiovascular Diseases.
Salvianolic acid B (Sal B), a polyphenolic constituent of Danshen. It has demonstrated therapeutic potential in cardiovascular diseases by targeting a spectrum of pathological processes. This review comprehensively summarizes the pharmacological effects, research progress and molecular mechanisms of Sal B cardiovascular protection, focusing on six aspects: antioxidant effect, anti-inflammatory activity, endothelial protective function, antifibrotic properties, inhibition of platelet aggregation and cardiomyocyte protection. This review also highlights advances over the past five years. It not only covers the discovery of new targets and new pathways (such as THBS1, Piezo1, p300); Innovative strategies to overcome its pharmacokinetic deficiencies were also discussed, including the development of advanced drug delivery systems such as responsive microspheres, dissolving microneedles, and biomimetic nanoparticles. This article aims to provide valuable reference for subsequent research by integrating these latest research results, and offers novel insights that can advancing the treatment development of Sal B for cardiovascular diseases.