Aug 2026
Structural landscape of a wide-open TPP: Insights into extreme conformational plasticity and allosteric potential.
The biochemical and structural characterization of Dermatophilus congolensis TPP is reported, which reveals a moderate catalytic turnover consistent with other bacterial orthologs and suggests a cryptic allosteric site that can be targeted to lock the enzyme in an inert state.
San Kim, Karthik Rajan Rajamanickam, H.-G. Woo et al.
· Biochemical and Biophysical... · 0 citations