Jul 2026
Abstract B063: A gene-editable human regulatory T-cell platform reveals USP22 as a regulator of FOXP3 stability and IFN-γ production
A flexible platform enabling high-purity isolation, expansion, functional profiling, and gene modification, using the oncogenic deubiquitinase USP22 as a reference target is established, revealing USP22 as a regulator of FOXP3 stability and IFN-γ production.
Shereen Kesserwan, Sarju Patel, Madison Greer et al.
· Clinical Cancer Research · 0 citations