Molecular Grammar of Intrinsically Disordered Regions: How Sequence and Context Shape Biomolecular Condensation and Disease
Intrinsically disordered regions (IDRs) are central components of many biomolecular condensates, where their sequence features help shape the weak and multivalent interactions underlying assembly and regulation. Aromatic and charged residues, sequence patterning, repeat motifs, and spacer properties can influence inter...